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Immunohistochemical determination of HER-2/neu, c-Kit (CD117), and vascular endothelial growth factor (VEGF) overexpression in malignant melanoma

✍ Scribed by Anil Potti; Nauman Moazzam; Eric Langness; Kaley Sholes; Ketki Tendulkar; Michael Koch; Steve Kargas

Publisher
Springer-Verlag
Year
2004
Tongue
English
Weight
196 KB
Volume
130
Category
Article
ISSN
1432-1335

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## Abstract Her‐2/__neu__ (__erb__B‐2) oncogene overexpression is associated with increased tumor progression and metastasis. Fatty acid synthase (FAS), the key lipogenic enzyme responsible for the endogenous synthesis of fatty acids, has been shown to be one of the genes regulated by Her‐2/__neu__