Detection of mutations in the DNA polyme
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Thomas Flohr; Jia-Chun Dai; Jens Büttner; Odilia Popanda; Egbert Hagmüller; Hein
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Article
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1999
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John Wiley and Sons
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French
⚖ 263 KB
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To test the hypothesis whether DNA polymerases acquire mutator properties during tumor development (mutator hypothesis), we examined DNA polymerase ␦ mRNA in 6 colon cancer cell lines (DLD-1, HCT116, SW48, HT29, SW480 and SW620) and 7 sporadic human colorectal cancers. For analysis we used amplifica