Immunohistochemical Detection of Hormone Receptors in Breast Carcinomas (ER-ICA, PgR-ICA): Prognostic Usefulness and Comparison with the Biochemical Radioactive-Ligand-Binding Assay (DCC)

Comparison of estrogen receptor determin

Comparison of estrogen receptor determinations by a biochemical ligand-binding assay and immunohistochemical staining with monoclonal antibody ER1D5 in females with lymph node positive breast carcinoma entered on two prospective clinical trials

✍ Steven R. Alberts; James N. Ingle; Patrick R. Roche; Stephen S. Cha; Lester E. W 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 830 KB

## BACKGROUND. The measurement of estrogen receptors (ER) in breast cancer specimens has traditionally been assessed with a tlextran-coated charcoal assay (DCCA). More recently the immunohistochemical staining (IHC) method has gained increasing popularity because of its ability to use fixed tissue