Germline mutations in the BRCA1 and BRCA2 genes are responsible for the predisposition and development of familial breast and/or ovarian cancer. Most mutations of BRCA1 and BRCA2 associated with breast and/or ovarian cancer result in truncated proteins. To investigate the presence of BRCA1 and BRCA2
Immunohistochemical detection of a germline BRCA1 mutation in a breast and ovarian cancer family
โ Scribed by A.C. Schofied; S. Payne; V.G. Ross; I.D. Miller; S.D. Heys; N.E. Haites
- Book ID
- 114482593
- Publisher
- Elsevier Science
- Year
- 2000
- Tongue
- English
- Weight
- 232 KB
- Volume
- 9
- Category
- Article
- ISSN
- 0960-9776
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The two major hereditary breast/ovarian cancer predisposition tumor suppressor genes, BRCA1 and BRCA2 that perform apparently generic cellular functions nonetheless cause tissue-specific syndromes in the human population when they are altered, or mutated in the germline. However, little is known abo
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