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Immunohistochemical demonstration of the placental form of glutathione S-transferase, a detoxifying enzyme in human gliomas

✍ Scribed by Akira Hara; Hiromu Yamada; Noboru Sakai; Hiroshi Hirayama; Takuji Tanaka; Hideki Mori


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
736 KB
Volume
66
Category
Article
ISSN
0008-543X

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## Abstract Carcinogenic polycyclic aromatic hydrocarbons(a) form DNA adducts via a complex metabolic activation pathway that includes cytochrome P450(a) 1A1, whereas intermediate metabolites can be detoxified by conjugation through pathways including glutathione s‐transferase M1 (GSTM1). PAH‐DNA a