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Immunohistochemical assessment of splenic lymphocyte and macrophage subpopulations in patients with gastric cancer

✍ Scribed by Stephan Falk; Gernot Seipelt; Hartmut Müller; Hans Jochen Stutte

Publisher
John Wiley and Sons
Year
1989
Tongue
English
Weight
733 KB
Volume
64
Category
Article
ISSN
0008-543X

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✦ Synopsis

In order to assess the effects of malignant tumors on the immune system, 25 spleens from patients with gastric carcinoma were studied by in situ immunohistochemical methods for lymphocyte subsets and cells of the mononuclear phagocyte system. Highly significant reductions of CD4+ T cells (P < 0.001), Ki M2+ and Ki M-3+ MPS cells ( P < 0.02 and P < 0.05), and a stage-dependent reduction of Ki 67+ B cell proliferation activity ( P < 0.05) were seen in spleens of patients with gastric cancer. These results, which were obtained by morphologic methods in a noninvolved lymphatic organ, reflect the systemic immunosuppressive and immunodepleting effects of malignant tumors that are probably mediated by tumor-associated cytokines.

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