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Immunohistochemical analysis of cyclin D1 and p53 in multiple myeloma

✍ Scribed by O. Markovic; D. Marisavljevic; V. Cemerikic; N. Suvajdzic; N. Milic; M. Colovic

Book ID
111640960
Publisher
Springer US
Year
2004
Tongue
English
Weight
103 KB
Volume
21
Category
Article
ISSN
1357-0560

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BACKGROUND. The t(11;14)(q13;q32) translocation with cyclin D1 overexpression commonly is found in multiple myeloma (MM) and in mantle cell lymphoma (MCL). Several reports have shown that p53 mutations in MCL lead to blastoid transformation and a worse prognosis; however, the role of p53 mutations i