Immunohistochemical analysis of 61 pituitary adenomas with a monoclonal antibody to the neuron-specific β-tubulin isotype
✍ Scribed by Shigeru Furuhata; Toru Kameya; Shigco Toya; Anthony Frankfurter
- Book ID
- 104673116
- Publisher
- Springer-Verlag
- Year
- 1993
- Tongue
- English
- Weight
- 539 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0001-6322
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✦ Synopsis
Pituitary adenomas surgically resected from 61 consecutive patients and 9 normal pituitary glands were studied by immunohistochemistry to determine the localization of the class III beta-tubulin isotype(neuron-specific) which is recognized by the monoclonal antibody TUJ1. In normal pituitary glands only a few cells were weakly immunopositive for TUJ1, whereas, in 43(73%) of 61 adenomas, more than 5% of tumor cells were immunopositive. The result may indicate that this neuron-specific beta-tubulin isotype may be either expressed de novo or enhanced under the transformation of pituitary acinar cells to tumors.