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Immunohistochemical Abnormalities of Fibrillin in Cardiovascular Tissues in Marfan’s Syndrome

✍ Scribed by Kirk J Fleischer; MD; Hossein C Nousari; MD; Grant J Anhalt; MD; Christopher D Stone; MD; John C Laschinger; MD

Book ID
117037504
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
322 KB
Volume
63
Category
Article
ISSN
0003-4975

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Marfan syndrome (MFS), a multisystem autosomal-dominant disorder, is characterized by mutations of the fibrillin-1 (FBNI) gene and by abnormal patterns of synthesis, secretion, and matrix deposition of the fibrillin protein. To determine the sensitivity and specificity of fibrillin protein abnormali