✦ LIBER ✦
Immunoglobulins M and D as antigen-binding receptors on the same cell, with shared specificity
✍ Scribed by C. Stern; I. McConnell
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- English
- Weight
- 291 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0014-2980
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Antigen‐binding cells specific for Type 3 pneumococcal polysaccharide were detected among normal human peripheral blood lymphocytes, tonsillar lymphocytes, and umbilical cord blood lymphocytes. By using μ and δ‐specific antiserum it was shown that some specific antigen‐binding cells simultaneously expressed both IgM and IgD on their surface. Both classes on individual cells were able to bind the same antigen, suggesting that the variable regions of each immunoglobulin class, when present on the same cell membrane, are coded by the same V gene.