Immunoglobulin-like domain is present in the extracellular part of the receptor tyrosine kinase from the marine sponge geodia cydonium
✍ Scribed by Heike Schäcke; Baruch Rinkevich; Vera Gamulin; Isabel M. Müller; Werner E. G. Müller
- Book ID
- 102372385
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 451 KB
- Volume
- 7
- Category
- Article
- ISSN
- 0952-3499
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✦ Synopsis
Abstract
We have isolated and characterized two cDNAs from the marine sponge Geodia cydonium coding for a new member of a receptor tyrosine kinase of class II. The deduced amino acid sequence shows two characteristic domains: (i) the tyrosine kinase domain; and (ii) and immunoglobulin‐like domain. The latter part shows high homology to the vertebrate C2 type immunoglobulin domain. This result demonstrates that immunoglobulin domains are not recent achievements of higher animals but exist also in those animals which have diverged from other organisms about 800 million years ago.