✦ LIBER ✦

Immunoglobulin light chain repertoire in hairy cell leukemia

✍ Scribed by Evgeny Arons; Tara Suntum; Joel Sunshine; Maryalice Stetler-Stevenson; Robert J. Kreitman

Publisher: Elsevier Science
Year: 2007
Tongue: English
Weight: 225 KB
Volume: 31
Category: Article
ISSN: 0145-2126
DOI: 10.1016/j.leukres.2006.11.019

No coin nor oath required. For personal study only.

✦ Synopsis

Of 166 hairy cell leukemia (HCL) patients, 81 had kappa and 80 had lambda expression. IGKV-J and IGLV-J rearrangement structure was analyzed in 21 HCL patients (11 kappa, 10 lambda). For kappa, IGKV1-5 was most frequent, and the KJ2 gene was over-utilized. For lambda HCL, LJ3 was over-utilized compared to normal. This study significantly adds to previous studies of light chain usage in HCL and is the first to report light chain gene usage. In HCL, we confirm the lack of kappa predominance observed in normal lymphocytes and in chronic lymphocytic leukemia, and note over-representation of several light chain genes.

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