Immunoglobulin and complement deposits in the lungs of New Zealand Black/White mice

✍ Scribed by D. M. Geddes; A. J. Leathem

• Book ID: 104781016
• Publisher: Springer
• Year: 1978
• Tongue: English
• Weight: 635 KB
• Volume: 378
• Category: Article
• ISSN: 1432-2307
• DOI: 10.1007/bf00465600

✦ Synopsis

The pattern of lung fluorescence was granular in association with capillary walls in 16 mice and intracellular in 12. The incidence of granular fluorescence was increased with age and was seen in 80% of the lungs of mice over 13 months old.

There was a correlation between capillary wall fluorescence in the lungs and the kidneys (P< 0.001) and between lung cellular fluorescence and renal mesangial fluorescence (P<0.001). The role of immune complex deposition in human pulmonary disease is discussed.