𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Immunoglobulin allotypes are not associated with HLA-antigens, autoantibodies and clinical symptoms in systemic lupus erythematosus

✍ Scribed by K. Hartung; R. Coldewey; E. Röther; K. Pirner; C. Specker; D. Schendel; W. Stangel; S. Stannat-Kießling; G. G. Lange

Book ID
104726293
Publisher
Springer
Year
1991
Tongue
English
Weight
403 KB
Volume
11
Category
Article
ISSN
0172-8172

No coin nor oath required. For personal study only.

✦ Synopsis

Immunoglobulin heavy chain (G1m, G2m, G3m, A2m) and kappa light chain (Km) allotype and phenotype frequencies of 323 central European Caucasian patients with systemic lupus erythematosus (SLE) were examined and correlated with various genetic, serologic and clinical markers of SLE. No significant associations were found between immunoglobulin allotypes or phenotypes and all 20 parameters tested (nephritis, vasculitis, arthralgias, photosensitivity, discoid lesions, central nervous system disease, Raynaud's phenomenon, sex, anti-Ro, anti-La, anti-nRNP, HLA-DR1-DR7, HLA phenotypes B8-DR3, B7-DR2). It could therefore be assumed that Gm, A2m and Km allotypes were not associated with HLA-antigens and had no influence on the serologic and clinical expression of SLE.

📜 SIMILAR VOLUMES

Clinical criteria for systemic lupus ery
Clinical criteria for systemic lupus erythematosus precede diagnosis, and associated autoantibodies are present before clinical symptoms
✍ Latisha D. Heinlen; Micah T. McClain; Joan Merrill; Yasmin W. Akbarali; Colin C. 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 144 KB

## Abstract ## Objective Specific events that occur during the development of systemic lupus erythematosus (SLE) can be quite variable among individual patients. The aim of this study was to identify patterns that distinguish early clinical events in SLE and to assess whether the presence of assoc