Immunogenicity of Therapeutic Proteins: The Use of Animal Models
โ Scribed by Vera Brinks; Wim Jiskoot; Huub Schellekens
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 156 KB
- Volume
- 28
- Category
- Article
- ISSN
- 0724-8741
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Antibody formation as an immune reaction to a 'foreign' protein antigen is an expected physiological reaction that is in many cases intentionally triggered, for example in the case of vaccinations. However, an unwanted immune response to a therapeutic protein may lead to a loss of efficacy and/or to
Unwanted immune responses to parenterally administered therapeutic proteins pose serious safety and economic risks, but the mechanism(s) by which these responses are generated are unknown. We measured immune responses to aggregates of recombinant murine growth hormone (mGH) formed by agitation or fr