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Immunogenicity of recombinant hepatitis B virus surface antigen fused with preS1 epitopes expressed in rice seeds

✍ Scribed by Bingjun Qian; Huifeng Shen; Wanqi Liang; Xiumei Guo; Chengmei Zhang; Yuan Wang; Guangdi Li; Aibo Wu; Kaiming Cao; Dabing Zhang


Book ID
118299933
Publisher
Springer Netherlands
Year
2007
Tongue
English
Weight
252 KB
Volume
17
Category
Article
ISSN
0962-8819

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Fusion of peptide epitopes to the core antigen (HBcAg) of hepatitis B virus (HBV) enhances their immunogenicity, both quantitatively and qualitatively. In a number of vaccine-induced mutants of HBV, glycine145 of the surface antigen S polypeptide (HBsAg) has been replaced by arginine, resulting in l