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Immunogenicity of interferon beta: differences among products

✍ Scribed by Antonio Bertolotto; Florian Deisenhammer; Paolo Gallo; Per Sölberg Sørensen

Book ID
106092666
Publisher
Springer
Year
2004
Tongue
English
Weight
283 KB
Volume
251
Category
Article
ISSN
0340-5354

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Aggregates play a major role in the immunogenicity of recombinant human interferon beta (rhIFNβ), a protein used to treat multiple sclerosis. A possible cause of aggregation is interaction between therapeutic protein and surfaces encountered during processing, storage, and administration. Moreover,