Immunogenicity in chimpanzees of experimental hepatitis B vaccines prepared from intact hepatitis B virus, purified polypeptides, or polypeptide micelles
✍ Scribed by Edward Tabor; Colin R. Howard; Jacinta Skelly; Philip Snoy; Alain Goudeau; Arie J. Zuckerman; Robert J. Gerety
- Publisher
- John Wiley and Sons
- Year
- 1982
- Tongue
- English
- Weight
- 621 KB
- Volume
- 10
- Category
- Article
- ISSN
- 0146-6615
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✦ Synopsis
Abstract
The immunogenicity of three experimental hepatitis B vaccines was evaluated in chimpanzees. Although no antibody to hepatitis B surface antigen (anti‐HBs) was detected in two chimpanzees that received an aqueous polypeptide vaccine subcutaneously, a strong anti‐HBs response was observed two and ten weeks, respectively, following challenge with hepatitis B virus. Inoculation of two additional chimpanzees with a micellar preparation of these polypeptides by the intravenous route resulted in anti‐HBs production in one of the chimpanzees. Two chimpanzees inoculated subcutaneously with an aqueous vaccine of formalin‐inactivated intact hepatitis B virus developed anti‐HBs in low titers, but the development of antibody to the hepatitis B core antigen following challenge inoculations suggested that subclinical HBV infections may have occurred despite prior vaccination.