Immunogenic and immunosuppressive components in soluble preparations from moloney murine leukemia virus-induced tumor cells
✍ Scribed by Phyllis B. Brandchaft; Tadao Aoki; Toby N. Silverman
- Publisher
- John Wiley and Sons
- Year
- 1976
- Tongue
- French
- Weight
- 630 KB
- Volume
- 17
- Category
- Article
- ISSN
- 0020-7136
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✦ Synopsis
Abstract
Soluble extracts from Moloney virus‐induced leukemia cells were shown to contain immunogenic and immunosuppressive components. Immunogenic components were divided into two classes based on their ability to: (1) combine with humoral antibody to inhibit cytotoxic activity; or (2) stimulate blastogenesis in normal syngeneic lymphocytes. Immunosuppressive components were demonstrated by the inhibition of DNA synthesis in normal syngeneic lymphocytes and suppression of a mixed lymphocyte reaction. Stimulating components in many soluble preparations were completely masked by immunosuppressive components. However, all three components could be resolved by Sephadex G200 chromatography.