𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Immunogenecity of hepatitis A vaccine in pediatric patients with inflammatory bowel disease

✍ Scribed by Andrzej Radzikowski; Aleksandra Banaszkiewicz; Izabella Łazowska-Przeorek; Urszula Grzybowska-Chlebowczyk; Halina Woś; Tomasz Pytrus; Barbara Iwańczak; Kinga Kowalska-Duplaga; Krzysztof Fyderek; Agnieszka Gawrońska; Katarzyna Karolewska-Bochenek; Maria Kotowska; Piotr Albrecht

Publisher
John Wiley and Sons
Year
2011
Tongue
English
Weight
421 KB
Volume
17
Category
Article
ISSN
1078-0998

No coin nor oath required. For personal study only.

✦ Synopsis

Background: There are only a few studies on immune response to routine vaccinations in children with inflammatory bowel disease (IBD), despite a strong need for this kind of study. The aim of the study was to evaluate the immunogenicity of an inactivated hepatitis A vaccine (HAV) in IBD pediatric patients compared with healthy controls.

Methods:

This was an open, prospective, and controlled study on anti-HAV-negative children and adolescents age 2-18 years with IBD. HAV using 720 enzyme-linked immunosorbent assay (ELISA) units were administered at 0 months and at 6-12 months. Seroconversion and geometric mean titers were measured after each vaccine dose. The evidence of local and systemic adverse effects for 3 days after the first and second dose of vaccine was registered.

Results: A total of 134 subjects (66 patients and 68 controls) completed the whole study course consisting of two doses of vaccine and six serum samples. There was no significant difference in the rate of seroconversion between IBD patients and controls when measured after the second dose of vaccine (97% versus 100%, P ¼ 0.2407), but the rate was significantly lower in the IBD group when measured after the first dose (39% versus 64%, P ¼ 0.00001). The mean geometric titers were statistically signifi-cantly lower in the IBD group than in the control group at all of the measured timepoints. There were no serious adverse events related to HAV during the study.

Conclusions: HAV is both immunogenic and safe in pediatric patients with IBD.

📜 SIMILAR VOLUMES

Cerebral thromboembolic events in pediat
Cerebral thromboembolic events in pediatric patients with inflammatory bowel disease
✍ A.R. Barclay; J.M. Keightley; I. Horrocks; V. Garrick; P. McGrogan; R.K. Russell 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 93 KB

## Background: There is a recognized association between pediatric inflammatory bowel disease (ibd) and cerebral thromboembolic events (ctes). historical reporting had described the association as strongest between ulcerative colitis (uc), rather than crohn's disease (cd). we describe the incidence

Development of extraintestinal manifesta
Development of extraintestinal manifestations in pediatric patients with inflammatory bowel disease
✍ Folashade Adebisi Jose; Elizabeth A. Garnett; Eric Vittinghoff; George D. Ferry; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 211 KB 👁 1 views

Background: Extraintestinal manifestations (EIMs) in pediatric patients with inflammatory bowel disease (IBD) are poorly characterized. We examined the prevalence of EIMs at diagnosis, subsequent incidence, and risk factors for EIMs. ## Methods: Data for 1649 patients from the PediIBD Consortium

Normal response to vaccines in inflammat
Normal response to vaccines in inflammatory bowel disease patients treated with thiopurines
✍ Iris Dotan; Lael Werner; Sharon Vigodman; Shradha Agarwal; Jorge Pfeffer; Noya H 📂 Article 📅 2012 🏛 John Wiley and Sons 🌐 English ⚖ 199 KB 👁 1 views

Background: Thiopurines are considered immunosuppressive agents and may be associated with an increased risk for infections. However, few inflammatory bowel disease (IBD) patients are appropriately vaccinated, and data on their ability to mount an immune response are vague. We evaluated the effects

Reduced muscle mass and bone size in ped
Reduced muscle mass and bone size in pediatric patients with inflammatory bowel disease
✍ Susanne Bechtold; Martin Alberer; Tina Arenz; Stefanie Putzker; Birgit Filipiak- 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 205 KB 👁 1 views

Background: Decreased bone mineral density has been reported in children with inflammatory bowel disease (IBD). We used peripheral quantitative computed tomography (pQCT) to assess bone mineralization, geometry, and muscle cross-sectional area (CSA) in pediatric IBD. ## Methods: In a cross-sectio