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Immunofluorescence studies on the expression of VHa allotypes by pre-B and B cells of homozygous and heterozygous rabbits

✍ Scribed by William E. Gathings; Rose G. Mage; Max D. Cooper; Alexander R. Lawton; Glendowlyn O. Young-Cooper


Publisher
John Wiley and Sons
Year
1981
Tongue
English
Weight
883 KB
Volume
11
Category
Article
ISSN
0014-2980

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The distribution of two heavy chain subgroups, VHa and VHy, on rabbit peripheral blood lymphocytes was examined by double membrane immunofluorescence. Fluroescent anti-a1 and anti-y33 were found to react with separate B cell populations; no doubly stained cells were observed. Further evidence for th

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✍ W.E. Gathings; A.R. Lawton; M.D. Cooper πŸ“‚ Article πŸ“… 1977 πŸ› John Wiley and Sons 🌐 English βš– 854 KB

## Abstract Immunofluorescent techniques were used to examine several aspects of B cell ontogeny in humans. Large lymphoid cells containing intracytoplasmic IgM (pre‐B cells) were present in fetal liver as early as 7 weeks of gestation, approximately 2 weeks prior to the appearance of surface IgM p