Background. Systemic amyloidosis leads to functional compromise of various organs through infiltration of these tissues by amyloid protein. The majority of affected patients develop infiltration of the thyroid gland; yet thyroid dysfunction rarely occurs. Methods and Results. Described herein is a
Immunoelectrophoretic investigations in 55 patients with systemic amyloidosis
โ Scribed by Durand, D. Vital ;Touraine, J.-L. ;Levrat, R. ;Zech, P. ;Traeger, J. ;Lejeune, E. ;Creyssel, R.
- Publisher
- Springer-Verlag
- Year
- 1984
- Weight
- 214 KB
- Volume
- 49
- Category
- Article
- ISSN
- 1432-0584
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โฆ Synopsis
Among 55 amyloidoses, the detection of a monoclonal protein (MP) led to the selection of 15 primary and 3 myeloma-associated types of amyloidosis. Therefore the presence of a MP gives evidence for an immunocytic amyloidosis.
The L-light-chain nature of MP and the abundant production of free lightchains are two of the factors predisposing to the production of amyloid deposits (AL) in the course of immunocyte dyscrasias.
๐ SIMILAR VOLUMES
At our center 62 renal transplantations (31 living donor and 31 cadaveric donor grafts) have been performed in 58 patients with amyloid renal disease since 1974. The amyloidosis was secondary to rheumatic disease in 74% of the patients. Predialytic transplantation was performed in 28% of the patient