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Immunodeficiency and Abnormal B Cell Synapse Formation due to DOCK8 Mutations in Mice

✍ Scribed by Katrina Randall; Teresa Lambe; Andy Johnson; Edyta Kucharska; Carola Vinuesa; Bebhinn Treanor; Facundo Batista; Tyani Chan; Tahra Camidge; Robert Brink; Richard Cornall; Chris Goodnow


Book ID
113541461
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
40 KB
Volume
135
Category
Article
ISSN
1090-2341

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πŸ“œ SIMILAR VOLUMES


Immune mechanisms leading to abnormal B
✍ Valerie Roy; Gabriel Bonventi; Yongchun Cai; Ralph MacLeod; Joan E. Wither πŸ“‚ Article πŸ“… 2007 πŸ› John Wiley and Sons 🌐 English βš– 450 KB

## Abstract Polyclonal B cell activation is a hallmark of the immune dysregulation in New Zealand Black (NZB) mice. We have previously shown that the splenic B cell activation is associated with increased CD80 expression. Here we show that abnormal expansions of CD80‐expressing GC, CD5^+^, marginal