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Immunocytochemical typing of primary tumors on fine-needle aspiration cytologies of lymph nodes

✍ Scribed by Alexandre Sherlley Casimiro Onofre; Natalia Pomjanski; Birgit Buckstegge; Alfred Böcking

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
210 KB
Volume
36
Category
Article
ISSN
8755-1039

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✦ Synopsis

Abstract

The aim of this study was to analyze the role of immunocytochemistry as an ancillary method on routine FNACs of enlarged lymph nodes, using different markers. In a validating cohort study all patients had confirmatory histological and/or clinical follow‐up. 10 FNACs were analyzed for the differentiation of Non‐Hodgkin Lymphoma (NHL) from metastatic carcinoma (MC), 30 cases to identify the sites of metastatic unknown primary tumors and 16 cases were checked to confirm clinical suspicion of a specific MC. Accuracy to differentiate NHL from MC was 100%, 92.3% to identify a primary tumor site of MC, and 100% to confirm a clinical suspicion of a specific MC. In 7 cases, the site of the primary tumor remained clinically unknown. Application of immunocytochemical markers on the same slide used for microscopic diagnosis is a useful tool in the routine assessment of FNACs of lymph nodes. Diagn. Cytopathol. 2008;36:207–215. © 2008 Wiley‐Liss, Inc.

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