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Immunocytochemical localization of the ?6 subunit of the ?-aminobutyric acidA receptor in the rat nervous system

✍ Scribed by Guti�rrez, Antonia; Khan, Zafar U.; De Blas, Angel L.

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
757 KB
Volume
365
Category
Article
ISSN
0021-9967

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✦ Synopsis

The localization in the rat central nervous system and retina of the a g subunit peptide of the y-aminobutyric acid (GABAA) receptor has been studied by light microscopy immunocytochemistry with a specific a n t k g antibody. The (Yg subunit was present in the granule cells of the cerebellum, the granule cells of the dorsal cochlear nucleus, axons of the olfactory nerve including the glomerular endings, layer I1 of the dorsal horn of the spinal cord, and in the retinal synaptic layers, particularly the inner plexiform layer. Thus, contrary to the general belief, the as subunit is not exclusively localized in the granule cells of the cerebellum. It is also expressed in some sensory neurons and other neurons involved in the initial processing of sensory information. 'L 1996 Wiley-Liss, Inc.

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