Immunocytochemical detection of epithelial cells in the bone marrow of primary breast cancer patients: a meta-analysis
✍ Scribed by Patrícia Weinschenker; Heloisa Prado Soares; Otavio Clark; Auro Del Giglio
- Publisher
- Springer US
- Year
- 2004
- Tongue
- English
- Weight
- 146 KB
- Volume
- 87
- Category
- Article
- ISSN
- 0167-6806
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Metastases develop in 30% to 40% of patients with operable breast cancer. Investigators have reported on the detection of occult micrometastases in bone marrow using an antibody to epithelial membrane antigen (EMA) and have since reported prognostic significance for these antibody-detected cells. In
Three different methods, morphologic, immunocytochemic, and fluorescence activated cell sorter (FC) analysis, were compared with respect to their efficiency in detecting breast cancer cells in bone marrow. In the first series of experiments, the three techniques were compared using bone marrow cells