Specific targeting of a mutant, activate
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David Hills; Gail Rowlinson-Busza; William J. Gullick
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Article
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1995
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John Wiley and Sons
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French
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## Abstract A truncated epidermal growth factor receptor (EGFR) expressed from a rearranged and amplified EGFR gene is present at high frequency in gliomas. In this work we show that when this receptor is expressed in NIH3T3 fibroblasts it is partially activated and confers tumorigenicity to this c