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Immunocytochemical abnormalities in a mouse model of spinal muscular atrophy

✍ Scribed by Mandler, Raúl N.; Allgood, Pam C.


Book ID
123292620
Publisher
Elsevier Science
Year
1992
Tongue
English
Weight
125 KB
Volume
8
Category
Article
ISSN
0887-8994

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## Abstract Deletions or mutations in __survival of motor neuron 1__ (__SMN1__) cause motor neuron loss and spinal muscular atrophy (SMA), a neuromuscular disorder, with the most severe type manifesting in utero. Whether SMA is a disease of defects in neurodevelopment and/or neuromaintenance remain