Immunochemical studies on the interrelationships between sulfite reductase and other NADPH-linked reductase activities of Escherichia coli and Salmonella typhimurium

Studies on the Interactions between Drug

Studies on the Interactions between Drugs and Estrogen: Analytical Method for Prediction System of Gynecomastia Induced by Drugs on the Inhibitory Metabolism of Estradiol Using Escherichia coli Coexpressing Human CYP3A4 with Human NADPH-Cytochrome P450 Reductase

✍ Takashi Satoh; Ken-ichi Fujita; Haruka Munakata; Shinji Itoh; Katsunori Nakamura 📂 Article 📅 2000 🏛 Elsevier Science 🌐 English ⚖ 94 KB

To establish a prediction system for drug-induced gynecomastia in clinical fields, a model reaction system was developed to explain numerically this side effect. The principle is based on the assumption that 50% inhibition concentration (IC 50 ) of drugs on the in vitro metabolism of estradiol (E2)