Immunobiology of pregnancy

✍ Scribed by Joan S Hunt

• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 856 KB
• Volume: 4
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/0952-7915(92)90032-a

✦ Synopsis

This report presents new findings on two conditions that permit genetically disparate tissues to coexist during pregnancy: (a) regulation of major histocompatibility genes in placental trophoblast, and (b) synthesis of uterine and placental polypeptide growth factors with immunosuppressive properties. Recent experiments examining inter-relationships between these two protective mechanisms are cited, and potential explanations for trophoblast resistance to factors with MHC-inducing properties are proposed.