Immunoassays of peptide hormones and their chemical aspects
✍ Scribed by L. Moroder; R. Nyfeler; M. Gemeiner; H. Kalbacher; E. Wüunsch
- Publisher
- Wiley (John Wiley & Sons)
- Year
- 1983
- Tongue
- English
- Weight
- 306 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0006-3525
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✦ Synopsis
Peptidchemie, 0-8033 Martinsried bei Munchen, Federal Republic of Germany
Synopsis
The N-terminal maleoyl-0-alanyl derivative of human gastrin-[2-17] has been synthesized as a model compound to investigate the usefulness of such peptide derivatives for their mild and selective conjugation, via reaction with thiol groups, to high-molecular-weight carrier molecules to produce antigens, as well as to radioiodinable or fluorogenic molecules to prepare tracers for immunoassays. In this context the examined enzyme substrate-gastrin conjugate was found to exhibit the full immunoreactivity of the parent peptide and to be well suited as tracer in a gastrin fluorescence-immunoassay.
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This review describes the neurological aspects of chemical terrorism with a focus on the civilian perspective. This review defines chemical threats as highly toxic chemicals that could be used in a terrorist attack, or those that could be released at toxic levels from transportation vehicles and sto