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Immunoadsorption model for a novel fluidized-bed blood detoxification device

✍ Scribed by Eric A. Grovender; Charles L. Cooney; Robert Langer; Guillermo A. Ameer

Book ID
102695810
Publisher
American Institute of Chemical Engineers
Year
2002
Tongue
English
Weight
761 KB
Volume
48
Category
Article
ISSN
0001-1541

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✦ Synopsis

Abstract

A multicompartment Taylor‐Couette flow hemofilter was designed to remove toxins from a patient's bloodstream via immunoadsorption. This device (Vortex Flow Plasmapheretic Reactor, VFPR) treats blood plasma with a fluidized‐bed of small (45–165×10^−6^ m diameter) particles, while protecting fragile blood cells from lysis. The potential application for the VFPR is dialysis‐related amyloidosis, a disease associated with the systemic accumulation of beta‐2‐microglobulin in patients with long‐term kidney failure. The equilibrium behavior of immunoadsorptive gel beads is characterized experimentally and theoretically using confocal microscopy and the Langmuir adsorption isotherm. The importance of external mass‐transfer resistance within the active compartment is assessed through dissolution studies conducted with benzoic acid particles. These results are combined with mass‐transfer fundamentals to develop a dynamic immunoadsorption model. The modeling results, without the use of adjustable parameters, agree with the experimental data and provide a foundation for further development and eventual application.

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