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Immunization with Biologically Active Fractions of Deoxyribonucleic Acid and Subsequent Specific Infection of Mice

✍ Scribed by KOHOUTOVÁ, M.


Book ID
109604218
Publisher
Nature Publishing Group
Year
1959
Tongue
English
Weight
207 KB
Volume
184
Category
Article
ISSN
0028-0836

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To target CD30 on Hodgkin's disease and anaplastic large-cell lymphoma, anti-CD30 single-chain antibodies were obtained by DNA immunization of mice with the complete human CD30 cDNA. Spleens were isolated from mice with high anti-CD30 titer, and the RNA was used for the production of an scFv-display