✦ LIBER ✦

Immunization of woodchucks with recombinant hepatitis delta antigen does not protect against hepatitis delta virus infection

✍ Scribed by Dr. Peter Karayiannis; John Saldanha; John Monjardino; Robert Goldin; Janice Main; Shashi Luther; Mark Easton; Antonio Ponzetto; Howard C. Thomas

Publisher: John Wiley and Sons
Year: 1990
Tongue: English
Weight: 404 KB
Volume: 12
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840120508

No coin nor oath required. For personal study only.

✦ Synopsis

To assess the role of immunization against hepatitis delta antigen in the prevention of hepatitis delta virus infection, woodchuck carriers of woodchuck hepatitis virus were immunized with a 64 amino acid portion of hepatitis delta antigen from its N-terminal region. The protein was expressed in E8cherichb coli and contained a major immunogenic epitope. A significant anti-hepatitis delta response was observed that did not, however, protect the animals from hepatitis delta virus superinfection. Unexpectedly, the period of detectable viremia was longer in the immunized than in the control animals. We conclude that immunization with this recombinant hepatitis delta antigen does not afford protection against subsequent hepatitis delta virus exposure. (HEPATOLOGY 1990;12:1125-1128.)

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