Immunity to experimental infection with Leishmania major: generation of protective L3T4+ T cell clones recognizing antigen(s) associated with live parasites
✍ Scribed by Ingrid Müller; Jacques A. Louis
- Publisher
- John Wiley and Sons
- Year
- 1989
- Tongue
- English
- Weight
- 827 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0014-2980
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✦ Synopsis
Immunity to experimental infection with Leishmania major: generation of protective L3T4' T cell clones recognizing antigen(s) associated with live parasites*
Exacerbation and resolution of lesions induced by Leishmania major promastigotes are, at least in part, the result of the activity of distinct parasite-specific L3T4' T lymphocytes. The present report describes L. major-specific cloned L3T4+ T lymphocytes capable of transferring substantial protective immunity to normal highly susceptible BALB/c mice. The two protective T cell clones analyzed appear to recognize antigen associated only with live L. major parasites. Therefore, the pattern of antigen reactivity of these protective T cell clones is different from that of the previously described parasite-specific L3T4' T cells which contribute to exacerbation of disease. The results presented in this report indicate that the two opposite effects of parasitespecific L3T4' T cells on the disease process could be mediated by functionally similar L3T4' T cells differing in their antigen specificity.