Front Cover
Immunity and Inflammation in Health and Disease
Copyright Page
Dedication
Contents
List of Contributors
Preface
I. Innate and Adaptive Immune Systems: Components and Regulation
1 Innate and Adaptive Immunity: Barriers and Receptor-Based Recognition
1.1 Introduction
1.2 The Components of the Immune Response (External and Internal Elements)
1.3 The Innate Immune System (Cell Types, Signaling)
1.4 Inflammation and Innate Immunity
1.5 Induction of Adaptive Immunity (Antigen Presentation as a Key Event)
1.6 Cell Types in the Adaptive Immune Response 1.7 Crosstalk Between the Innate and Adaptive Immune Responses1.8 The Vascular Endothelium as a Converging Site for Both Innate and Adaptive Immunity
1.9 Chronic Diseases of the Innate and Adaptive Immune Systems
1.10 Improving Immunity for Prevention and Care
1.11 Summary
References
2 Innate Immunity at Birth: Implications for Inflammation and Infection in Newborns
2.1 Introduction
2.2 Microbiome in Shaping the Newborn Immune System
2.3 Mucosal Immunity at Birth
2.4 The Innate Immune Cells of the Newborn
2.4.1 Neonatal Neutrophils
2.4.2 Neonatal Monocytes 2.4.3 Neonatal Macrophages2.4.4 Neonatal Dendritic Cells
2.4.5 Neonatal Natural Killer (NK) Cells
2.5 Soluble Plasma Components
2.6 Conclusion
References
3 Redox Signaling and the Onset of the Inflammatory Cascade
3.1 Introduction
3.2 ROS Generation During the Onset of the Inflammatory Cascade
3.3 Redox Control of Inflammatory Mediators
3.4 Redox Control of Antioxidant and Anti-inflammatory Transcription Factors
3.5 Emerging Role of Peroxiredoxins in the Onset of the Inflammatory Cascade
3.6 Conclusions and Perspectives
References II. Reactive Oxygen Species, Oxidative Stress and Immune Cell Activation4 Reactive Oxygen Species, Oxidative Damage and Cell Death
4.1 Introduction
4.2 Endogenous ROS Production
4.3 Exogenous ROS Production
4.4 Physiological Role of Reactive Oxygen Species
4.5 Oxidative Stress
4.6 Oxidative Damage is Outcome of Oxidative Stress
4.7 Cell Death
4.8 Conclusions
References
5 Mitochondrial ROS and T Cell Activation
5.1 Introduction
5.2 Reactive Oxygen Species
5.3 Sources of Mitochondrial ROS
5.4 Regulation of mROS
5.5 Targets of mROS
5.6 Mitochondrial ROS in T Cell Activation 5.7 SummaryReferences
6 Overcoming Oxidants and Inflammation: Endothelial Targeting of Antioxidants to Combat Chronic Inflammatory Disease
6.1 Introduction
6.2 Inflammation and Disease
6.2.1 Vascular Endothelium, Reactive Species, and Inflammatory Agents
6.2.2 Markers of Oxidative Stress and Inflammation
6.3 Antioxidants as therapeutics
6.4 Antioxidant Targeting Strategies
6.5 Nanocarrier-Mediated Delivery of Antioxidants
6.5.1 Liposomes
6.5.2 Polymer Nanocarriers
6.5.3 Magnetic Nanoparticles
6.5.4 Lipid Nanoparticles and Complexes
6.6 Conclusions
References