Immunity against solid tumors?
β Scribed by Rolf M. Zinkernagel
- Book ID
- 102269273
- Publisher
- John Wiley and Sons
- Year
- 2001
- Tongue
- French
- Weight
- 92 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0020-7136
- DOI
- 10.1002/ijc.1305
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Clinical trials of tumor-antigen-specific immunization have clearly shown that immune-mediated tumor rejection requires more than simple T cell-target cell interactions. In vivo generation of tumor-specific T cells is one of a series of steps necessary for the induction of clinically relevant immune
## Abstract The incidence of spontaneous tumors was studied in a group of 136 female mice and in another group of 138 females after a sublethal dose of total body irradiation. Of the nonirradiated mice 10.2% developed mammary tumors, and 8% developed lung tumors. Of the irradiated mice 19.5% develo