To elucidate the role of host immune status in the evolution and complexity of hepatitis C virus (HCV) quasispecies, three chronic HCV-infected patients who underwent bone marrow transplantation (BMT) were studied. The three transplanted patients' sera were sampled at pre-BMT, 3 months after BMT, an
Immune tolerance to hepatitis C virus acquired during engraftment of bone marrow transplant
β Scribed by A. Godkin; P. Openshaw; H. C. Thomas
- Book ID
- 108885790
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 151 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1352-0504
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Recipients of allogeneic bone marrow transplantation are immunosuppressed as a result of their primary disease and by myeloablative therapy. Such patients are dependent on multiple blood products and are at risk for hepatitis B v i r u s infection. Active immunization against hepatitis B in the imme
Recipients of allogeneic bone marrow transplantation are pancytopenic for several weeks and immunosuppressed for many months as a result of myeloablative therapy required to eliminate the basic disease and to prevent allograft rejection. After bone marrow transplantation, these patients remain profo