Immune restoration in head and neck cancer patients after in vivo COX-2 inhibition
β Scribed by Stephan Lang; Sanjay Tiwari; Michaela Andratschke; Iren Loehr; Lina Lauffer; Christoph Bergmann; Brigitte Mack; Annette Lebeau; Andreas Moosmann; Theresa L. Whiteside; Reinhard Zeidler
- Book ID
- 105967233
- Publisher
- Springer-Verlag
- Year
- 2007
- Tongue
- English
- Weight
- 397 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0340-7004
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## Abstract ## __Background.__ Cyclooxygenaseβ2 (COXβ2) is an enzyme involved in the synthesis of prostaglandins and thromboxanes, which are regulators of processes such as inflammation, cell proliferation, and angiogenesis, all relevant for cancer development. We investigated whether functional g
## Abstract The immune reactivity of 100 head and neck cancer patients was studied by means of DNCB, candidine, blastic transformation with PHA, and lymphocyte counts. DNCB reactivity was strong in only 21% of the population and was found impaired in patients with advanced primitive tumors, with m