## Abstract Despite intensive treatment, 70% of the ovarian cancer patients will develop recurrent disease, emphasizing the need for new approaches such as immunotherapy. A promising antigenic target for immunotherapy in ovarian cancer is the frequently overexpressed p53 protein. The aim of the stu
โฆ LIBER โฆ
Immune responses to p53 in patients with cancer:enrichment in tetramer+ p53 peptide-specific T cells and regulatory T cells at tumor sites
โ Scribed by Andreas E. Albers; Robert L. Ferris; Grace G. Kim; Kazuaki Chikamatsu; Albert B. DeLeo; Theresa L. Whiteside
- Publisher
- Springer-Verlag
- Year
- 2005
- Tongue
- English
- Weight
- 380 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0340-7004
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Peptides derived from mutated ras are immunogenic in mice and humans, and represent a group of specific tumor antigens that are potential targets for immunotherapy. T-cell responses against mutant p2I ras can be initiated in vitro by repeated stimulation of peripheral-blood mononuclear cells with mu