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Immune responses to defined epitopes of the circumsporozoite protein of the murine malaria parasite, Plasmodium yoelii

✍ Scribed by Didier Grillot; Martine Michel; Ingrid Müller; Chantal Tougne; Laurent Rènia; Dominique Mazier; Giampietro Corradin; Paul-henri Lambert; Jacques A. Louis; Giuseppe del Giudice


Publisher
John Wiley and Sons
Year
1990
Tongue
English
Weight
849 KB
Volume
20
Category
Article
ISSN
0014-2980

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The C terminus of the circumsporozoite protein (CSP) is anchored to the parasite cell membrane by a glycosylphosphatidylinositol (GPI) glycolipid. This GPI signal sequence functions poorly in heterologous eukaryotic cells, causing CSP retention within internal cell organelles during genetic immuniza