Immune responses against domain I of β2-glycoprotein I are driven by conformational changes: Domain I of β2-glycoprotein I harbors a cryptic immunogenic epitope

Some antiphospholipid antibodies recogni

Some antiphospholipid antibodies recognize conformational epitopes shared by β2-glycoprotein I and the homologous catalytic domains of several serine proteases

✍ Wei-Shiang Lin; Pei-Chih Chen; Cheng-De Yang; EunJung Cho; Bevra H. Hahn; Jennif 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 120 KB

## Abstract ## Objective To test the hypothesis that some antiphospholipid antibodies (aPL) in patients with the antiphospholipid syndrome (APS) recognize a conformational epitope shared by β~2~‐glycoprotein I (β~2~GPI; the major autoantigen for the antiphospholipid antibodies) and the homologous