✦ LIBER ✦

Immune response of patients with congenital coagulation disorders to hepatitis b vaccine: Suboptimal response and human immunodeficiency virus infection

✍ Scribed by Elizabeth J. Miller; Christine A. Lee; Sue Holmes; P. B. A. Kernoff; H. C. Thomas; P. Karayiannis

Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 452 KB
Volume: 28
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890280208

No coin nor oath required. For personal study only.

✦ Synopsis

Seventy-eight patients with congenital coagulation disorders were treated with hepatitis B vaccine either subcutaneously or intradermally. All the children (eight vaccinated subcutaneously and eight vaccinated intradermally) responded. Seventeen of 19 (goo/,) anti-HIV-negative adults vaccinated subcutaneously and 14/25 (56Y0) anti-HIV-negative adults vaccinated intradermally showed an immune response. At 24 months, the anti-HBs level was > 10 IU/I in all children vaccinated subcutaneously, 83% of children vaccinated intradermally, 77% of adults vaccinated subcutaneously, and 55% of adults vaccinated intradermally. Eight of 15 (53%) adult patients who were anti-HIV positive were also anti-HBc positive before vaccination and 6/8 (75%) failed to produce an amnestic response to vaccine. Subcutaneous vaccination with regular monitoring of anti-HBs levels and appropriate boosting is recommended.

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