๐”– Bobbio Scriptorium
โœฆ   LIBER   โœฆ

Immune response of adults to sequential influenza vaccination

โœ Scribed by Robert D. Powers; Frederick G. Hayden; Joel Samuelson; Jack M. Gwaltney Jr.

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
356 KB
Volume
14
Category
Article
ISSN
0146-6615

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โœฆ Synopsis

Annual immunization against influenza is recommended for numerous individuals, but the antibody response to sequential vaccination has not been well characterized. Levels of hemagglutination-inhibition antibody were measured in adults given either two or three doses of trivalent influenza vaccine at six-month intervals. A significant rise in the number of individuals with antibody titers of 240 was seen for all three antigens only after initial vaccination. Repeated vaccination was necessary to maintain adequate antibody levels only to the A/Brazil (HlN1) antigen; it did not significantly affect the proportions of individuals with protective levels of antibody to either the AlBangkok (H3N2) or the B/Singapore 222/79 antigens. These findings do not support the current recommendation for annual immunization when the vaccine formulation has not changed.

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