Immune regulation and B-cell depletion therapy in patients with primary Sjögren’s syndrome
✍ Scribed by Wayel H. Abdulahad; Frans G.M. Kroese; Arjan Vissink; Hendrika Bootsma
- Book ID
- 116614393
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 256 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0896-8411
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## Abstract ## Objective To delineate disturbances in peripheral B cell memory in primary Sjögren's syndrome (SS). ## Methods Isotype‐specific immunoglobulin (Ig) heavy‐chain transcripts were analyzed in single‐sorted CD19+,CD27− naive and CD19+,CD27+ memory B cells from patients with primary SS
In 43 women and 3 men suffering from primary Sjögren's syndrome pulmonary function was correlated to various clinical, haematological and serological disease activity parameters. Primary Sjögren's syndrome was defined as the presence of keratoconjunctivitis sicca and xerostomia, in the absence of ot