Immune reconstitution in HIV infection

✍ Scribed by Sean Emery; H Clifford Lane

• Book ID: 104358734
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 479 KB
• Volume: 9
• Category: Article
• ISSN: 0952-7915
• DOI: 10.1016/s0952-7915(97)80112-4

✦ Synopsis

Progressive immune deficiency arising during HIV disease reflects the continual degradation and the ultimate deletion of immune specificites defined by the CD4 + T lymphocyte repertoire. Recent evidence suggests that improvements in the immune function of patients with HIV who receive therapy primarily reflects the expansion of CD4 + T lymphocyte populations present before therapy commenced. These observations have implications for clinical management, therapeutic strategieS, and future research.