Gpbar1 (TGR5), a membrane-bound bile acid receptor, is well known for its roles in regulation of energy homeostasis and glucose metabolism. TGR5 also displays strong attenuation of macrophage reactivity in vitro, but the physiological roles of TGR5 in inflammatory response, and its mechanism, is unk
โฆ LIBER โฆ
Immune receptor expressed on myeloid cells 1 (IREM-1) inhibits B cell activation factor (BAFF)-mediated inflammatory regulation of THP-1 cells through modulation of the activities of extracellular regulated kinase (ERK)
โ Scribed by S.-M. Lee; Y.-P. Nam; K. Suk; W.-H. Lee
- Book ID
- 108701255
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 459 KB
- Volume
- 161
- Category
- Article
- ISSN
- 0009-9104
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Although the cytokine-inducible transcription factor signal transducer and activator of transcription 5 (STAT5) promotes proliferation of a wide range of cell types, there are cell-specific and context-specific cases in which loss of STAT5 results in enhanced cell proliferation. Here, we report that