Immune modulation of collagen-induced arthritis by intranasal cytokine gene delivery: A model for the therapy of rheumatoid arthritis

An opposing time-dependent immune-modula

An opposing time-dependent immune-modulating effect of the sympathetic nervous system conferred by altering the cytokine profile in the local lymph nodes and spleen of mice with type II collagen–induced arthritis

✍ Peter Härle; Daniel Möbius; Daniel J. J. Carr; Jürgen Schölmerich; Rainer H. Str 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 154 KB 👁 1 views

## Abstract ## Objective The sympathetic nervous system (SNS) seems to play a proinflammatory role in the early asymptomatic phase of arthritis, but its role in the late stages of chronic arthritis is not well known. The purpose of this study was to examine the effects of the SNS on late‐stage chr