The process of thymic selection is critical for the generation of the mature T-cell repertoire, yet the nature of the self-peptides that serve this function is not known. Several studies suggest that tissue-specific auto-antigens are expressed in the thymus. We initiated this study to examine the ex
Immune markers for monitoring the progression of autoimmune disease
β Scribed by Nanette C. Schloot; Paolo Pozzilli; Thomas Mandrup-Poulsen
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 70 KB
- Volume
- 15
- Category
- Article
- ISSN
- 1520-7552
No coin nor oath required. For personal study only.
β¦ Synopsis
The incidence of immune-mediated diseases is increasing worldwide. Reliable immune markers for monitoring disease progression and also the effect of therapeutic interventions are urgently needed in order to investigate preventive or therapeutic measures effectively. At a recent workshop held on 5 December 1998 in Copenhagen, the state of research on surrogate markers in Type 1 diabetes was discussed and compared with the experience in multiple sclerosis, inflammatory bowel disease and transplantation.
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