Immune Dysfunction and Immunotherapy in Heart Disease

• Publisher: Blackwell Publishing
• Year: 2007
• Tongue: English
• Leaves: 315
• Category: Library

✦ Synopsis

Current heart failure therapeutics affects symptoms without appreciably reducing the mortality rate of 50% in five years -- suggesting a failure in treating the underlying mechanism. This book proposes a new mechanism for heart failure; immune mediated cardiac remodelling for cardiac dysfunction.

The outstanding editor team of two internationally recognized immunologists -- Ronald Watson, who has studied heart disease in immune dysfunction for a decade and has a patent for an immunotherapy of heart disease by immune regulation, and Douglas Larson, whose experience in cardiac transplantation immunology has provided the foundation for research into novel therapeutics for heart failure and hypertension - makes Immune Dysfunction and Immunotherapy in Heart Disease the definitive reference to the state of the science in this area.

The four parts of the book address:

• 
  
• Immune Dysfunction Leading to Heart Disease: Induction by Physiological Changes
  
• Immune Dysfunction Promoting CVD: Induction by Transplantation Drugs
  
• Immune Dysfunction Leading to Heart Dysfunction: Induction or Prevention by Cardiotherapeutic Drugs
  
• Immune Dysfunction Leading to Heart Disease: Induction by Pathogens

Both researchers and practitioners will find this authoritative volume an excellent source of information on novel immune targeted therapeutics.

Content:
Chapter 1 Immunosuppression by Ultraviolet Light?B Radiation: A Mediator of Cardiac Remodeling (pages 3–5): Sherma Zibadi, Douglas F. Larson and Ronald Ross Watson
Chapter 2 Immune Mechanisms in Pediatric Cardiovascular Disease (pages 6–16): Wendy A. Luce, Mandar S. Joshi, Timothy M. Hoffman, Timothy F. Feltes and John Anthony Bauer
Chapter 3 Heart Failure—Role of Autoimmunity (pages 17–27): Urs Eriksson
Chapter 4 Immune Basis of Hypertension in Humans (pages 28–33): Katherine Horak and Douglas F. Larson
Chapter 5 Immune Dysregulation: Potential Mediator of Metabolic Syndrome—Induced Cardiac Remodeling (pages 34–38): Sherma Zibadi, Douglas F. Larson and Ronald Ross Watson
Chapter 6 T Helper 2 Cell Cytokines in Remodeling of Aortic Wall (pages 39–47): W. L. Chan
Chapter 7 Effects of TNF?? on Cardiac Function (pages 48–56): Bo Yang and Douglas F. Larson
Chapter 8 Immunosuppression in Promotion of Cardiac Allograft Vasculopathy (pages 57–79): Farzad Moien?Afshari, Jonathan Choy, Bruce M. McManus and Ismail Laher
Chapter 9 Immunotherapy for Left Ventricular Dysfunction After Heart Transplantation (pages 80–94): Charles E. Canter
Chapter 10 Immunomodulating Therapy in Chronic Heart Failure (pages 97–108): Lars Gullestad, Jan Kristian Damas, Arne Yndestad and Pal Aukrust
Chapter 11 Statins in Atherosclerosis: Role of Immune Regulation (pages 109–115): Claire Arnaud and Francois Mach
Chapter 12 ACE Inhibitors as Immunomodulators: Treatment of Cardiovascular Disease (pages 116–127): Christina Grothusen and Bernhard Schieffer
Chapter 13 Treatment of Heart Failure by Anticytokine Therapies (pages 128–132): Donna L. Vredevoe and Julia R. Gage
Chapter 14 Pathogenesis of Cardiovascular Complications in the Acquired Immunodeficiency Syndrome (pages 135–151): Giuseppe Barbaro
Chapter 15 Cytokines and T Cell?Mediated Responses in Autoimmune Myocarditis (pages 152–156): Jin Zhang
Chapter 16 Drugs of Abuse: Accentuation of Immunomodulation of Viral Myocarditis (pages 157–171): Oana Madalina Petrescu and James P. Morgan
Chapter 17 Osteopontin: The Link Between the Immune System and Cardiac Remodeling (pages 175–181): Samira Najmaii, Qianli Yu and Douglas F. Larson
Chapter 18 Inflammatory Immune Activation in Heart Failure Patients: Therapeutic Implications (pages 182–185): Mohammad Abraham Kazemizadeh Gol and Mohsen Araghi?Niknam
Chapter 19 Role of Innate Immune Dysregulation in Diabetic Heart Failure (pages 186–194): Betsy B. Dokken and Paul F. McDonagh
Chapter 20 Tolerance in Heart Transplantation: Current and Future Role (pages 195–206): Kimberly Gandy, Jos Domen and Jack Copeland
Chapter 21 Neutralization of Th2 Cytokines in Therapy of Cardiovascular Pathology (pages 207–216): A. Mandel and A. E. Bolton
Chapter 22 Anti?Inflammatory Immune Therapy in Heart Disease (pages 217–226): David Chen, Christian Assad?Kottner, Francisco J. Cordova, Carlos Orrego and Guillermo Torre?Amione
Chapter 23 Cholesterol, Interleukin?6 Inflammation, and Atherosclerosis—Role of Statins, Bisphosphonates, and Plant Polyphenols in Atherosclerosis and Other Diseases of Aging (pages 227–255): Sota Omoigui
Chapter 24 Autoimmune Myocarditis: Treatment with Anti?T?Cell Antibodies (pages 256–262): Zofia T. Bilinska and Witold Ruzyllo
Chapter 25 Immunosuppressive Therapy to Counter Cardiac Allograft Vasculopathy (pages 263–270): Carl V. Leier
Chapter 26 Role of Oral Pathogens in the Pathogenesis of Coronary Heart Disease (pages 271–279): Palle Holmstrup
Chapter 27 Myocardial Regenerative Potential by Stem Cell Transplant (pages 280–287): Yinhong Chen, Catherine A. Priest and Joseph D. Gold
Chapter 28 Bioflavanoids and Dietary Anti?Inflammatory Actions: Role in Cardiovascular Diseases (pages 288–300): Simin Bolourchi?Vaghefi and Amy Galena